RAF Typhoon FGR4s have operated alongside France's air force in a coordinated attack against an hidden munitions depot in Syria used by the IS group, according to the British defence ministry.
The facility, pinpointed through intelligence, was thought to be containing munitions and bombs, the statement said, and was situated in mountains just above the ancient city of Palmyra in Syria's central region.
"Our aircraft utilized laser-guided Paveway IV weapons to target a series of entry passages down to the facility... early reports are that the objective was successfully hit," the MoD said.
There was no sign of any civilian impact in the attack on Saturday evening and every plane involved made a safe return, the ministry further stated.
The Typhoon FGR4s were assisted by a Voyager aerial refuelling aircraft.
IS - also known as the so-called Islamic State - established militant control over parts of Iraq and Syria prior to its 2019 collapse.
"This action demonstrates the UK's leading role, and resolve to operate in unison with allied nations, to stamp out any re-emergence of IS and their violent and radical beliefs in the Middle East," UK Defence Secretary the minister remarked.
British military aircraft have conducted surveillance missions over Syrian airspace to "forestall any attempted resurgence" of Islamic State after its defeat at the climactic battle in Baghuz in the year 2019, the authorities noted.
"I extend gratitude to the personnel of our armed forces participating in this strike for their professionalism and their valour," he said. "They were among numerous British personnel stationed over the holidays. This action, to eliminate terrorist threats who threaten our way of life, shows how UK forces are ready to step up, continuously, keeping Britain secure domestically and powerful internationally."
Last December, the American forces conducted what it termed a "large-scale strike" against Daesh sites in Syria, after an ambush claimed the lives of two American soldiers and a civilian interpreter in Palmyra.
The United Nations estimates Daesh still has between 5,000 and 7,000 militants in Syria and Iraq.
